Product Name :
PKC iota Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
aPKC lambda/iota antibody aPKC-lambda/iota antibody Atypical protein kinase C lambda/iota antibody Atypical protein kinase C-lambda/iota antibody DXS1179E antibody KPCI_HUMAN antibody MGC26534 antibody nPKC iota antibody nPKC-iota antibody nPKCiota antibody 展开
Function :
Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. May play a role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. Functions in both pro- and anti-apoptotic pathways. Functions in the RAC1/ERK signaling required for transformed growth. Plays a role in microtubule dynamics through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs).
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human PKC iota/PKCI 181-280/596
Species reactivity:
Human, Mouse, Rat, Pig, Cow, Horse, Sheep
Verify application:
WB, IHC-P, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.143415-31-0 manufacturer When reconstituted in sterile pH 7.(S)-3-Aminobutanenitrile hydrochloride web 4 0.PMID:33438191 01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
68 KDa
Positive control :
Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers.