Product Name :
20-HETE-d6
Synonym :
20-hydroxy Arachidonic Acid-d6
Application :
20-HETE-d6 is an internal standard for quantification of 20-HETE by GC- or LC-mass spectrometry
CAS:
Purity:
≥99%
Molecular Weight:
326.5
Formula :
C20H26D6O3
Physical state:
Liquid
solubility :
Shipping Condition :
Store at -20° C
Melting point:
SMILES:
[2H]C([2H])(CCO)C([2H])([2H])C([2H])([2H])/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)O
References:
:20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells. | Nilakantan, V., et al. 2008. Am J Physiol Renal Physiol. 294: F562-70. PMID: 18171997CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis. | Antoun, J., et al. 2008. J Lipid Res. 49: 2135-41. PMID: 1856647520-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease. | Park, F., et al. 2008. J Am Soc Nephrol. 19: 1929-39. PMID: 18596124Intravenous formulation of N-hydroxy-N′-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for inhibition of rat brain 20-hydroxyeicosatetraenoic acid formation. | Mu, Y., et al. 2008. Drug Metab Dispos. 36: 2324-30. PMID: 18725506Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. | Park, F., et al. 2009. Am J Physiol Renal Physiol. 296: F575-82. PMID: 19129252Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury. | Hoff, U., et al. 2011. Kidney Int. 79: 57-65. PMID: 20962739Cytochrome P450 omega -hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. | Yu, W., et al. 2011. Cancer Chemother Pharmacol. 68: 619-29. PMID: 21120482Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures.1-Chloropyrrolo[1,2-c]pyrimidine Purity | Renic, M., et al. 2012. Am J Physiol Heart Circ Physiol. 302: H1285-93. PMID: 2224577420-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway.638217-08-0 uses | Lai, G.PMID:33402004 , et al. 2012. Mol Endocrinol. 26: 1907-16. PMID: 2291887620-HETE is associated with unfavorable outcomes in subarachnoid hemorrhage patients. | Donnelly, MK., et al. 2015. J Cereb Blood Flow Metab. 35: 1515-22. PMID: 2592095620-Hydroxyeicosatetraenoic Acid Is a Key Mediator of Angiotensin II-induced Apoptosis in Cardiac Myocytes. | Zhao, H., et al. 2015. J Cardiovasc Pharmacol. 66: 86-95. PMID: 2616472220-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3 beta /Glut2 pathway. | Zhang, B., et al. 2016. Endocrine. 54: 371-382. PMID: 27568038Upregulation of 20-HETE Synthetic Cytochrome P450 Isoforms by Oxygen-Glucose Deprivation in Cortical Neurons. | Zhang, H., et al. 2017. Cell Mol Neurobiol. 37: 1279-1286. PMID: 2811048420-HETE regulated PSMB5 expression via TGF- beta /Smad signaling pathway. | Lai, G., et al. 2018. Prostaglandins Other Lipid Mediat. 134: 123-130. PMID: 28807746