Product Name :
3-Deazauridine (CAS 23205-42-7)
Synonym :
Application :
3-Deazauridine is an antimetabolite antiviral (Flaviviridae) for proteomics research
CAS:
23205-42-7
Purity:
Molecular Weight:
243.21
Formula :
C10H13NO6
Physical state:
Solid
solubility :
Soluble in DMSO, methanol, and water.
Shipping Condition :
Store at -20° C
Melting point:
>207° C (dec.)
SMILES:
C1=CN(C(=O)C=C1O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
References:
:3-Deazauridine triggers dose-dependent apoptosis in myeloid leukemia cells and enhances retinoic acid-induced granulocytic differentiation of HL-60 cells. | Savickiene, J. and Gineitis, A. 2003. Int J Biochem Cell Biol. 35: 1482-94. PMID: 128182433-Deazauridine enhances the antileukemic action of 5-aza-2′-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase. | Raynal, NJ., et al. 2011. Leuk Res. 35: 110-8. PMID: 20510451The effect of 3-deazauridine and dipyridamole on uridine utilization by mice. | Moyer, JD., et al. 1986. Eur J Cancer Clin Oncol. 22: 323-7. PMID: 2423341Chemotherapy of L1210 and L1210/ARA-C leukemia with 5-aza-2′-deoxycytidine and 3-deazauridine. | Momparler, RL. and Momparler, LF. 1989. Cancer Chemother Pharmacol. 25: 51-4. PMID: 2480188Inhibition of RNA virus replication in vitro by 3-deazacytidine and 3-deazauridine. | Khare, GP., et al. 1972. Proc Soc Exp Biol Med. 140: 880-4. PMID: 4339065Drug sequence-dependent toxicity and small bowel mucosal injury in mice treated with low doses of 3-deazauridine and 1-beta-D-arabinofuranosylcytosine.159857-80-4 custom synthesis | Paterson, AR.5467-74-3 custom synthesis , et al.PMID:33665872 1979. Cancer Res. 39: 2216-9. PMID: 4454203-Deazauridine: inhibition of ribonucleic acid virus-induced cytopathogenic effects in vitro. | Shannon, WM., et al. 1972. Antimicrob Agents Chemother. 2: 159-63. PMID: 4799550Regulation of pyrimidine biosynthesis in cultured L1210 cells by 3-deazauridine. | Karle, JM. and Cysyk, RL. 1984. Biochem Pharmacol. 33: 3739-42. PMID: 6095859Altered 5-azacytidine metabolism following 3-deazauridine treatment of L5178Y and human myeloblasts. | Grant, S. and Cadman, E. 1980. Cancer Res. 40: 4000-6. PMID: 6162541Transport of uridine and 3-deazauridine in cultured human lymphoblastoid cells. | Dahlig-Harley, E., et al. 1984. Cancer Res. 44: 161-5. PMID: 6580947Cytotoxic and biochemical effects of thymidine and 3-deazauridine on human tumor cells. | Lockshin, A., et al. 1984. Cancer Res. 44: 2534-9. PMID: 6722792The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate. | van Berg, AA., et al. 1995. Biochem Pharmacol. 50: 1095-8. PMID: 7575666Effects of 2-deoxy-D-glucose and 3 deazauridine individually and in combination on the replication of Japanese B encephalitis virus. | Woodman, DR. and Williams, JC. 1977. Antimicrob Agents Chemother. 11: 475-81. PMID: 856001